Multi-omics analysis reveals new pathogenic methylation sites, genes, and potential regulatory pathways in essential hypertension - PubMed
5 hours ago
- #multi-omics
- #essential hypertension
- #DNA methylation
- Identified 767 methylation sites, 159 blood genes, and 111 arterial genes linked to essential hypertension (EH).
- Found 41 genes consistently associated with EH in both blood and arterial tissues, with eight (FDFT1, FES, GNL3, NME6, SLC22A5, UBA7, ULK3, ZNF589) annotated from EH-relevant methylation sites.
- Drug target analysis highlighted 64 compounds targeting FDFT1, FES, ULK3, and SLC22A5.
- SMR analysis revealed 72 and 79 significant methylation-related regulatory pathways for EH in single blood tissue and cross-tissue analyses, respectively.
- Methylation of FES influenced its expression in blood and arterial tissues, affecting EH risk, suggesting a potential new regulatory pathway.
- The findings offer insights for developing EH biomarkers and therapies through multi-omics approaches.