Regulatory B Cells at the Crossroads of Epigenetic Control and Immune Homeostasis - PubMed
3 hours ago
- #immune regulation
- #B cells
- #epigenetics
- Regulatory B cells (Bregs) work with regulatory T cells (Tregs) to maintain immune tolerance.
- IL-10-producing Bregs are key suppressors in autoimmunity and cancer.
- Histone deacetylases (HDACs) act as an epigenetic switch controlling IL-10 expression and Breg identity.
- Blimp-1, STAT3, and c-Maf integrate signals like LPS and IL-21 to regulate chromatin via HDACs.
- BACH2 and HDAC3 restrain Prdm1 to limit plasmablast-like Breg differentiation.
- Breg-Treg crosstalk via molecules like CD40/CD40L and PD-1/PD-L1 suppresses Th1/Th17 effectors.
- Breg deficiencies promote autoimmunity, while Breg expansion in tumors impairs anti-cancer immunity.
- Epigenetic strategies could enhance Bregs for autoimmune therapy or disrupt tumor-associated Bregs for cancer treatment.