Sphingosine-1-phosphate induces pulmonary artery smooth muscle cell proliferation, migration and pulmonary arterial remodeling by modulating sonic hedgehog signaling effector FoxM1 - PubMed
5 hours ago
- #Sphingosine-1-phosphate
- #Sonic hedgehog signaling
- #Pulmonary hypertension
- Sphingosine-1-phosphate (S1P) induces pulmonary artery smooth muscle cell (PASMC) proliferation, migration, and pulmonary arterial remodeling.
- S1P activates STAT3, leading to increased Shh expression, Gli1 upregulation, and nuclear translocation in PASMCs.
- Gli1 activation raises FoxM1 expression, triggering PASMC proliferation and migration.
- In MCT-induced PAH rat models, elevated S1P levels activate STAT3, upregulating Shh, Gli1, and FoxM1 in lung tissues.
- Targeting S1P/STAT3/Shh/Gli1/FoxM1 pathway molecules alleviates pulmonary arterial remodeling and prevents PAH development.