SLIT3 fragments orchestrate neurovascular expansion and thermogenesis in brown adipose tissue - PubMed
3 hours ago
- #thermogenesis
- #neurovascular
- #SLIT3
- SLIT3 fragments, specifically SLIT3-N and SLIT3-C, coordinate neurovascular expansion and thermogenesis in brown adipose tissue (BAT).
- Adipocyte progenitors secrete SLIT3, which is cleaved by BMP1, with SLIT3-C acting through PLXNA1 receptor to promote sympathetic innervation and SLIT3-N aiding angiogenesis.
- This bifurcated mechanism ensures synchronized BAT response to cold exposure, regulating adaptive thermogenesis and body temperature in placental mammals.
- The study reveals adipocyte progenitors play a previously unrecognized role in tissue innervation, highlighting a key signaling pathway for BAT function.