Dynamic impact of intermittent fasting and refeeding on metabolic health and microbiome-metabolome signatures in cynomolgus monkeys - PubMed
a day ago
- #intermittent-fasting
- #microbiome
- #metabolic-health
- The study investigates the effects of intermittent fasting (IF) and refeeding on metabolic health and microbiome-metabolome signatures in overweight female cynomolgus monkeys.
- An IF regimen of 20-hour fasting/4-hour feeding for 84 days was followed by a 42-day post-intervention phase with either continued IF or normal feeding.
- Results showed significant reductions in body weight, serum triglycerides, insulin levels, and insulin resistance in overweight monkeys due to IF.
- Insulin-lowering effects and improved insulin sensitivity persisted even after reintroduction of normal feeding.
- Continuous IF led to a sustained increase in lymphocyte-to-neutrophil ratio, suggesting immunomodulatory effects.
- Limited compositional changes in gut microbiota were observed, with time-dependent enrichments in genera like Ruminococcus and Eubacterium_hallii_group.
- Serum metabolomics revealed significant time-dependent alterations in circulating metabolites.
- The study provides insights into metabolic adaptations to IF-refeeding in non-human primates and sets a foundation for further research.