Reinventing the wheel in ischemic stroke: Novel aspects in ADAMTS13 and von Willebrand axis - PubMed
3 hours ago
- #ADAMTS13
- #VWF
- #Ischemic Stroke
- ADAMTS13 is an enzyme that cleaves ultra-large von Willebrand factor (VWF) multimers.
- ADAMTS13 deficiency leads to thrombotic thrombocytopenic purpura (TTP), a condition causing micro-thrombosis in small vessels.
- Reduced ADAMTS13 activity in long-term TTP survivors is linked to major cardiovascular events.
- The dysregulation of the ADAMTS13/VWF axis plays a role in the pathogenesis of ischemic stroke (IS).
- There is a need for novel predictive models and targeted therapeutics for IS outcomes.
- The review aims to summarize experimental and clinical evidence on the therapeutic potential of VWF-ADAMTS13 in IS.
- Future research perspectives in this domain are also discussed.