The structure and function of taste G protein-coupled receptors and their implications in diseases - PubMed
3 hours ago
- #Therapeutic Targets
- #Disease Mechanisms
- #Taste GPCRs
- Taste GPCRs like TAS1Rs (sweet) and TAS2Rs (bitter) detect nutrients and toxins, affecting diet and health.
- They are expressed beyond taste buds in respiratory, GI systems, regulating immunity, hormones, and energy.
- Malfunctions or variations in these receptors are associated with diseases including asthma, diabetes, obesity, dental issues, and cancers.
- Structural and signaling features of taste GPCRs underpin their diverse functions and therapeutic potential.
- They are promising targets for treating metabolic syndrome and immune disorders, with ongoing research in molecular modeling.