A tumor-associated photoreceptor signature unifies distinct central nervous system malignancies - PubMed
5 days ago
- #pineoblastoma
- #photoreceptor-signature
- #CNS-malignancies
- Pineoblastoma is an aggressive childhood brain tumor with distinct molecular subgroups.
- Single-cell transcriptomes from pineal tumors trace origins to transient pinealocyte progenitors.
- Lineage-specific driver perturbations create models representing molecular subgroups.
- A tumor-associated photoreceptor signature (TAPS) is common to pineoblastoma, retinoblastoma, and Group 3 medulloblastoma.
- Photoreceptor signature components are selective dependencies in these CNS malignancies.
- Findings suggest developmentally encoded programs as potential therapeutic targets.