D-Dimer: A Mediator of the Association Between Lymphocyte and Dissemination of Pulmonary Tuberculosis: A Retrospective Cohort Study - PubMed
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- #D-dimer
- #tuberculosis
- #lymphocyte
- D-dimer and lymphocyte counts predict the risk of concurrent pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB).
- Higher D-dimer levels increase the risk of PTB + EPTB (adjusted OR = 2.28, 95% CI: 1.99-2.60).
- Higher lymphocyte counts reduce the risk of PTB + EPTB (adjusted OR = 0.25, 95% CI: 0.13-0.46).
- Critical thresholds identified: D-dimer > 0.170 mg/L (OR = 2.35, 95% CI: 2.05-2.70) and lymphocytes > 750 cells/μL (OR = 0.15, 95% CI: 0.07-0.32).
- D-dimer mediates 36.473% (95% CI: 25.469-53.168) of the protective effect of lymphocytes against TB dissemination.