The Association Between the Aggregate Index of Systemic Inflammation (AISI) and Prevalence of Psoriasis: Cross Sectional NHANES Study 2003-2006 and 2009-2014 - PubMed
3 hours ago
- #NHANES
- #psoriasis
- #systemic inflammation
- The study examines the association between the Aggregate Index of Systemic Inflammation (AISI) and psoriasis prevalence in U.S. adults using NHANES data from 2003-2006 and 2009-2014.
- Higher AISI levels were independently associated with increased odds of psoriasis, indicating a correlation with systemic inflammation.
- The analysis included 17,776 participants, with multivariable logistic regression showing a significant trend (p < 0.001).
- Restricted cubic spline analyses revealed an approximately linear positive association between ln-transformed AISI and psoriasis prevalence.
- Subgroup analyses showed no significant interactions, suggesting consistency in the association across different categories.
- Receiver operating characteristic analysis indicated AISI had limited discriminatory ability for psoriasis (AUC = 0.58).
- The study concludes that AISI is a correlate of systemic inflammation rather than a predictive or causal marker for psoriasis.