NMRK2-YAP-NADK axis preserves redox protection against myocardial ischemia/reperfusion injury - PubMed
3 hours ago
- #NADK
- #Myocardial ischemia-reperfusion
- #Redox protection
- NMRK2 is upregulated after reperfusion and provides redox protection in myocardial ischemia/reperfusion (I/R) injury.
- NMRK2 enhances antioxidant capacity by increasing NADPH, restoring NAD+/NADH ratio, and activating Trx1.
- NADK knockdown abolishes NMRK2's protective effects, indicating its crucial role in redox protection.
- NMRK2 disrupts the integrin β-YAP interaction, leading to YAP nuclear entry and NADK transcriptional activation.
- YAP directly binds to the NADK promoter (-1500 to -1000 bp) to activate its transcription.
- The NMRK2-YAP-NADK axis offers a potential therapeutic target for myocardial I/R injury.