Paramagnetic Rim Lesions in Highly Active Multiple Sclerosis at the Time of Disease Diagnosis: Prevalence Data and Clinical Implications - PubMed
4 hours ago
- #MRI Biomarkers
- #Neuroinflammation
- #Multiple Sclerosis
- Paramagnetic rim lesions (PRLs) are emerging MRI biomarkers for smoldering inflammation in multiple sclerosis (MS) with prognostic relevance.
- Study investigates prevalence, anatomical distribution, and clinical significance of PRLs in newly diagnosed relapsing MS patients with high disease activity.
- PRLs were detected in 76% of patients, with a mean of 4.9 lesions per subject.
- Higher PRL burden correlated with greater T2 lesion volume, cortical lesion count, higher EDSS scores, reduced cognitive scores (SDMT), and elevated baseline serum neurofilament light chain (sNfL).
- PRLs remained stable over 12 months despite treatment, with two new PRLs emerging at month 12.
- sNfL levels were higher in patients with ≥4 PRLs but decreased in all during follow-up.
- Combined assessment of PRLs and cortical lesions (CLs) may improve disease monitoring and guide personalized treatment.