Blimp-1 integrates alarmin signals in ILC2s and drives proinflammatory functions required for type 2 immunity - PubMed
4 hours ago
- #Type 2 immunity
- #ILC2
- #Blimp-1
- Blimp-1 is identified as an IL-33-regulated transcription factor in Group 2 innate lymphoid cells (ILC2s).
- Blimp-1 is essential for ILC2 effector functions, including type 2 cytokine production (IL-5, IL-13), eosinophilia, and worm expulsion, but not for ILC2 development.
- The study reveals a reciprocal Blimp-1-IRF4 regulatory circuit downstream of the IL-33 receptor in ILC2s.
- IL-25, IL-33, and TSLP are alarmins that activate ILC2s and are linked to allergic inflammation.
- The Blimp-1-IRF4 axis is highlighted as an alarmin-regulated transcriptional network controlling ILC2-driven type 2 immunity.