Editing-independent effects of Drosophila Adar on heterochromatin silencing - PubMed
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- #RNA editing
- #Heterochromatin silencing
- #ADAR
- ADAR RNA editing enzymes convert adenosines to inosines in dsRNA.
- Drosophila AdarG isoform inhibits HP1-mediated heterochromatin silencing of repetitive sequences.
- Overexpression of AdarG or catalytically inactive AdarE374A causes larval lethality and ecdysone-related defects.
- Adar overexpression leads to elevated innate immune and early ecdysone gene transcript expression.
- RNAi knockdown of EcRA or increased HP1 expression partially rescues AdarG overexpression defects.
- AdarG inhibits histone H3K9me-mediated epigenetic silencing, likely at the dsRNA/Dcr2/Ago2 initiation stage.