Gut microbial ammonia enhances colonic acetylcholine levels to regulate intestinal motility - PubMed
9 hours ago
- #acetylcholine
- #intestinal motility
- #gut microbiome
- Gut microbial ammonia enhances colonic acetylcholine (ACh) levels to regulate intestinal motility.
- Compensatory elevation of intestinal ammonia levels and urease activity observed in mouse models of intestinal dysmotility and constipation patients.
- Ammonia supplementation or intervention with urease-positive bacteria restored colonic ACh levels in mice.
- In vitro, ammonia upregulated voltage-gated calcium channels on enteric neurons, driving Ca2+ influx to potentiate ACh secretion.
- Study reveals a microbial compensatory mechanism responding to fluctuating ACh levels, offering microbial targets for motility disorders.