Human-specific features of the cerebellum and ZP2-regulated synapse development - PubMed
a day ago
- #cerebellum
- #synapse development
- #ZP2
- Study focuses on human-specific features of the cerebellum and ZP2-regulated synapse development.
- Single-nucleus transcriptomic and chromatin accessibility profiling was conducted in humans, chimpanzees, macaques, and marmosets.
- Human-specific transcriptomic and regulatory features, especially in synaptogenesis, were identified.
- Zona pellucida glycoprotein 2 (ZP2) and its interactors were found enriched in human granule cells (GCs).
- ZP2 expression in human GCs is induced by pontine mossy fibers, reducing synaptic proteins and electrophysiological activity.
- Findings suggest a human-specific role for ZP2 in synapse regulation, contributing to cerebellar evolutionary specialization.