RAD51C-XRCC3 complex regulates FANCM-mediated R-loop resolution to safeguard genome integrity - PubMed
9 hours ago
- #RAD51C-XRCC3 complex
- #FANCM
- #R-loop resolution
- The RAD51C-XRCC3 (CX3) complex plays a role in the Fanconi anemia (FA) pathway by regulating R-loop tolerance mechanisms.
- CX3 complex suppresses R-loops, transcription-replication collisions (TRCs), and associated genome instability under physiological and replication stress conditions.
- The CX3 complex physically interacts with FANCM, facilitating its recruitment to R-loop sites to promote resolution.
- Cells with the RAD51C R258H pathological mutant show defective interaction with FANCM and inefficient R-loop processing.
- The CX3 complex-mediated R-loop resolution is independent of its fork maintenance function.
- This study reveals a new role for the CX3 complex in preventing R-loop-induced genome instability by regulating FANCM activity.