Herpes simplex virus 1 fluidizes the nucleus, enabling condensate formation - PubMed
4 days ago
- #HSV-1
- #nuclear fluidity
- #viral replication
- Herpes simplex virus 1 (HSV-1) increases nuclear fluidity to promote condensate formation.
- The HSV-1 protein ICP4 is responsible for nuclear fluidization and enables synthetic nuclear condensate growth.
- Reduced nuclear fluidity inhibits viral replication compartment condensates and decreases virus production.
- ICP4 helps overcome nuclear crowding and elastic confinement, facilitating HSV-1 replication.
- The study suggests ICP4's role in modifying nuclear biophysics to support the HSV-1 life cycle.