Disulfidptosis: A novel cell death mechanism with pathological significance and therapeutic potential in diseases - PubMed
a day ago
- #therapeutic target
- #cell death
- #disease intervention
- Disulfidptosis is a newly identified form of programmed cell death involving disulfide stress-induced cytoskeletal disintegration.
- Key pathways include SLC7A11-mediated cystine uptake, NADPH depletion, and aberrant disulfide accumulation leading to actin collapse and cell death.
- It differs from other cell death mechanisms like apoptosis, necroptosis, and ferroptosis, offering unique therapeutic potential.
- Targeting disulfidptosis can restore cellular homeostasis in diseases such as cancer, neurodegeneration, and autoimmune disorders.
- Therapeutic strategies are bidirectional: inducing disulfidptosis to kill cancer cells or inhibiting it to protect healthy cells.
- The discovery provides new approaches for treating previously intractable diseases by targeting redox imbalance and disulfide stress.