Polymersomes preventing brain infiltration of CD177+ neutrophils to mitigate hemorrhagic transformation post-tPA thrombolysis - PubMed
4 hours ago
- #polymersomes
- #hemorrhagic transformation
- #tPA thrombolysis
- Developed ROS-triggered polymersomes conjugated with fibrin-targeting CREKA peptide for tPA encapsulation to target thrombosis and enhance thrombolysis.
- Discovered tPA-induced hemorrhagic transformation linked to CD177 expression; loaded recombinant CD177 into polymersomes to block CD177+ neutrophil migration into the brain.
- rCD177 release in response to ROS prevents neutrophil migration by interacting with CD31 on endothelial cells, reducing neutrophil extracellular traps (NETs) formation.
- Reduced NETs dampen microglia inflammatory activation, improving hemorrhagic transformation prognosis post-thrombolysis.
- This strategy offers a promising approach to mitigate hemorrhagic complications following tPA thrombolysis in stroke treatment.