Enhanced Immunotherapy for Glioblastoma Using a Cholesterol Oxidase-Loaded, Pd-Doped Cu3N Nanozyme-Based Multimodal Nanoplatform - PubMed
10 hours ago
- #nanozyme nanoplatform
- #ferroptosis cuproptosis
- #glioblastoma immunotherapy
- Development of a multimodal nanoplatform called Cu3PdN@CR for enhanced glioblastoma immunotherapy.
- The nanoplatform incorporates Pd-doped Cu3N nanozyme, cholesterol oxidase, and RVG29 peptide for BBB penetration and targeting.
- Mechanisms include metabolic disruption, sonodynamic ROS generation, ferroptosis/cuproptosis induction, and cholesterol depletion to downregulate PD-L1.
- In orthotopic GBM models, the approach suppresses tumor growth, prolongs survival, and shows no systemic toxicity.