Epigenetic inhibition of class I histone deacetylases by MS-275 attenuates diabetic skeletal muscle atrophy via Akt/ARK5-FoxO and myostatin-Smad signaling - PubMed
6 hours ago
- #diabetes
- #muscle atrophy
- #epigenetics
- MS-275, a class I HDAC inhibitor, attenuates skeletal muscle atrophy in diabetic db/db mice.
- Treatment reduces inflammation, macrophage infiltration, and NF-κB activation in muscle tissue.
- MS-275 lowers myostatin levels and suppresses Smad2/3 signaling, reducing catabolic pathways.
- Akt and ARK5 phosphorylation is restored, leading to FoxO1/3 phosphorylation and decreased MuRF1 and atrogin-1 expression.
- Epigenetic inhibition of HDACs coordinately targets inflammation and signaling pathways to preserve muscle mass in diabetic sarcopenia.