Bifidobacterium Pseudolongum-Derived Acetate Attenuates Acute Pancreatitis Through GPR43-Mediated Suppression of M1 Macrophage Polarization - PubMed
3 hours ago
- #metabolism
- #microbiota
- #immunology
- Bifidobacterium pseudolongum alleviates pancreatic damage, inflammation, and apoptosis in acute pancreatitis (AP) mouse models.
- The probiotic's protective effect is linked to enhanced gut barrier function and microbiota diversity.
- Acetate, produced by B. pseudolongum via the ackA gene, is identified as the key metabolite.
- Acetate supplementation protects against AP through GPR43-mediated inhibition of M1 macrophage polarization.
- Clinical data show reduced fecal B. pseudolongum abundance in AP patients, correlating with disease severity.
- Findings suggest B. pseudolongum and acetate as potential therapeutic strategies for AP.