Human umbilical cord-derived mesenchymal stem cell exosomes ameliorate hepatocyte ferroptosis and sepsis-associated liver injury by restoring iron homeostasis in hepatocytes - PubMed
3 hours ago
- #sepsis
- #liver injury
- #ferroptosis
- Human umbilical cord-derived mesenchymal stem cell exosomes (HUMSCs-Exo) can mitigate hepatocyte ferroptosis and sepsis-associated liver injury (SALI).
- HUMSCs-Exo restore iron homeostasis in hepatocytes by modulating key proteins like FPN, xCT, GPX4, FTH1, ACSL4, and TFRC.
- These exosomes reduce intracellular lipid peroxidation and labile iron accumulation, thereby protecting against liver injury.
- The study validates findings in both murine and human hepatocyte cell lines, suggesting a novel therapeutic strategy for SALI.