Mitochondrial translational control in cardiovascular diseases: from mechanisms to therapies - PubMed
3 hours ago
- #Cardiovascular Diseases
- #Mitochondrial Translation
- #Therapeutic Strategies
- Mitochondria maintain cardiac metabolic homeostasis, and their dysfunction is central to cardiovascular diseases (CVDs).
- Only 13 mitochondrial genes encode OXPHOS subunits, with their translation inside mitochondria tightly regulated by environmental and metabolic cues.
- Key regulatory processes include mitoribosome biogenesis, tRNA modifications, and translation-inner membrane assembly coupling.
- Upstream mechanisms like redox signaling, mitoepigenetics, and mitochondria-localized microRNAs (mitomiRs) modulate translation under stress.
- Mitochondrial translation is dysregulated in conditions such as ischemia-reperfusion injury, cardiac hypertrophy, heart failure, and inherited cardiomyopathies.
- Therapeutic strategies focus on restoring translational fidelity, including pharmacology, metabolic tuning, and mitochondrial gene editing.
- Targeting mitochondrial translation offers a new approach to treat CVDs and enhance myocardial resilience.