Structural remodeling of the mitochondrial protein biogenesis machinery under proteostatic stress - PubMed
8 hours ago
- #cryo-EM
- #proteostasis
- #mitochondria
- Mitochondrial proteostatic stress leads to structural remodeling of cristae and reduced ribosome complexes.
- Mitochondrial Hsp60 (mHsp60) undergoes conformational changes favoring complexes with its co-chaperone mHsp10 during stress.
- Cryo-electron microscopy reveals mHsp60's functional cycle and its role in mitochondrial proteostasis.
- The study provides insights into mitochondrial protein biosynthesis and its adaptation under proteostatic stress.