Cornuside Alleviates Microglia-Mediated Neuroinflammation to Ameliorate Chronic Neuropathic Pain-induced Cognitive Impairment via the Nrf2/Sirt3 Signaling Pathway - PubMed
3 hours ago
- #Nrf2/Sirt3 Pathway
- #Neuroinflammation
- #Cognitive Impairment
- Cornuside, derived from Cornus officinalis, shows potential in treating cognitive impairment caused by chronic neuropathic pain (CNP-CI).
- The study highlights cornuside's ability to reduce microglia-mediated neuroinflammation and improve cognitive functions via the Nrf2/Sirt3 pathway.
- Activation of the Nrf2/Sirt3 signaling pathway and enhancement of mitophagy are key mechanisms through which cornuside exerts its effects.
- Inhibition of Sirt3 negates the therapeutic benefits of cornuside, underscoring the pathway's importance in its mechanism of action.
- The findings suggest cornuside as a promising therapeutic candidate for CNP-CI, offering new insights into its pharmacological properties.