Invasive Fusariosis Among Patients with Acute Leukemia: A 12-Year Single-Center Experience in a Middle-Income Country - PubMed
4 days ago
- #Invasive fusariosis
- #Acute leukemia
- #Fungal infection
- Invasive fusariosis (IF) is a severe mold infection in acute leukemia patients, with rapid dissemination and high mortality.
- A 12-year retrospective study in a middle-income country analyzed 26 acute leukemia patients with IF.
- Most patients (84.6%) had disseminated disease, with cutaneous lesions (73%) and pulmonary involvement (31%) common.
- Antifungal prophylaxis was used in 69.2% of cases, mainly fluconazole or anidulafungin.
- Treatment involved lipid formulations of amphotericin B, alone or combined with voriconazole.
- 30-day mortality was 38.5%, higher in patients undergoing re-induction therapy and lower with antifungal prophylaxis.