TET CpG sequence-context-specific DNA demethylation shapes progression of IDH-mutant gliomas - PubMed
3 hours ago
- #DNA-methylation
- #TET enzymes
- #IDH-mutant glioma
- TET CpG sequence-context-specific DNA demethylation influences IDH-mutant glioma progression.
- Study involves 302 oligodendroglioma resections, analyzing Ki-67 staining, proteomics, and DNA methylation.
- Tumor progression shows a continuum of DNA methylation changes linked to epigenetic aging and Ki-67+ cell density.
- Large-scale DNA demethylation correlates with TET enzyme-preferred CpG flanking sequences.
- Findings confirmed in astrocytomas, suggesting a shared epigenetic progression axis in IDH-mutant gliomas.
- Development of a DNA methylation-based continuous grading coefficient (CGC��) outperforms WHO grading for prognosis.
- Highlights the potential of DNA methylation-based grading for better tumor biology reflection and clinical decisions.