Progerin expression in humans: Implications for natural ageing - PubMed
3 days ago
- #Biomarker
- #Progerin
- #Ageing
- Progerin is a truncated lamin A isoform linked to Hutchinson-Gilford Progeria Syndrome (HGPS) and natural ageing.
- Low-level progerin is found in normal tissues like skin, vasculature, and blood cells, contributing to cellular ageing processes.
- Progerin causes nuclear deformation, DNA damage, telomere attrition, and premature senescence, aligning with ageing theories.
- Endogenous suppressors like WRN helicase and telomere-protective factors help modulate progerin levels and mitigate its effects.
- Progerin provides insights into vascular and dermal ageing, complementing systemic measures like epigenetic clocks.
- Standardized ultrasensitive assays and longitudinal studies are needed to validate progerin as part of ageing biomarker panels.
- Progerin may serve as a mechanistic link between premature and physiological ageing, aiding biomarker strategies.