Bacterial genomic structural variations in children with autism serve as diagnostic biomarkers - PubMed
4 hours ago
- #microbiome
- #biomarkers
- #autism
- Gut microbiota dysbiosis is linked to autism spectrum disorder (ASD) in children.
- Study identified 100 bacterial structural variations (SVs) significantly associated with ASD.
- SVs were enriched in genes involved in ion and amino acid metabolism and bacterial growth regulation.
- Key SVs found in Bacteroides uniformis (thiamine and iron metabolism) and Ruminococcus torques (MazF/MazE system).
- Validation in humanised mouse models linked SV signatures to ASD-like behaviors.
- Diagnostic model combining nine SVs and three bacterial species achieved 81.1% accuracy.
- Bacterial genomic SVs show potential as diagnostic biomarkers for ASD.