Skin bacteriota ameliorates androgenetic alopecia via harmonizing skin immuno inflammatory balance - PubMed
5 hours ago
- #skin microbiome
- #androgenetic alopecia
- #inflammatory balance
- The study investigates the effect of skin microbiome on hair growth in androgenetic alopecia (AGA) model mice.
- Antibiotic-treated (ABT) mice showed sparse hair, thinner skin, and fewer hair follicles compared to antibiotic-free (ABF) mice, but co-housing improved these conditions.
- Key proteins and mRNA levels related to hair growth (β-catenin, Wnt5a, Vegfa, Fgfr, Igf1, Lef1) decreased in ABT mice but recovered in co-housed ABF/ABT mice.
- Increased expression of inflammatory markers (TLR4, NF-κB, IL-6, Il-17) in ABT mice indicated skin inflammation, which was notably affected by co-housing.
- 16S rDNA sequencing suggested Lactobacillus and Proteus as key genera influencing immuno-inflammatory balance.
- Restoring skin bacteriota promotes hair growth in AGA mice, likely by modulating the skin’s inflammatory microenvironment via TLR4/NF-κB pathways.
- The study highlights the potential for bacterial-based therapies in treating AGA.