Real-time intraocular pressure monitoring and responsive drug release in preclinical models by an all-polymer smart contact lens - PubMed
4 hours ago
- #smart contact lens
- #intraocular pressure monitoring
- #glaucoma
- Development of a battery-free, all-polymer microfluidic theranostic smart contact lens (AP-TSCL) for glaucoma management.
- AP-TSCL enables real-time intraocular pressure (IOP) monitoring and autonomous, IOP-responsive drug release without bulky electronics.
- Device integrates noninvasive microfluidic IOP sensor with multistage, pressure-gated drug delivery architecture for staged release from multiple reservoirs.
- Demonstrated efficacy in in vitro, ex vivo (bovine eyes), and in vivo (rabbit) models, achieving IOP tracking and lowering comparable to conventional topical therapy.
- Aims to overcome limitations of poor patient adherence and static measurements in current glaucoma treatments, offering a personalized, clinically translatable solution.