Effectiveness of non-pharmacological and pharmacological interventions in preventing delirium in older adults: a systematic review and meta-analysis of randomised controlled trials - PubMed
8 hours ago
- #meta-analysis
- #older-adults
- #delirium-prevention
- Non-pharmacological multicomponent interventions significantly reduce delirium occurrence in older adults (RR=0.56, 95% CI 0.45-0.72) compared to usual care.
- Dexmedetomidine is effective in reducing delirium risk (RR=0.49, 95% CI 0.43-0.57) for non-cardiovascular surgical patients.
- Corticosteroids and intranasal insulin show significant effects based on a small number of trials, with high-certainty evidence.
- Single-component non-pharmacological interventions show mixed or inconclusive findings for delirium prevention.
- Mixed strategies, such as haemodynamic or cerebral oxygen-guided approaches, suggest potential benefit but are heterogeneous.
- Overall certainty of evidence is low to very low, highlighting the need for further high-quality randomised trials.