Coupling of functionality to trafficking of KCNQ2/3 potassium channels at the axon initial segment - PubMed
4 hours ago
- #neuronal excitability
- #KCNQ2/3
- #axon initial segment
- KCNQ2/3 potassium channels at the axon initial segment (AIS) regulate neuronal excitability.
- Functionality of KCNQ2/3 is controlled by voltage sensing, while AIS localization is regulated by ankyrinG (ankG).
- Study reveals coupling between KCNQ2/3 functionality and trafficking mechanisms.
- Single-molecule imaging shows reduced KCNQ3 functionality affects trafficking, reducing AIS localization.
- Active conformation of KCNQ3 is essential for stable ankG binding.
- Findings provide a mechanistic basis for integrating KCNQ2/3 gating and trafficking in neuronal excitability regulation.