Peripheral immune-inducer dendritic cells drive early-life allergic inflammation - PubMed
3 hours ago
- #dendritic cells
- #allergy
- #immune response
- Early-life exposure to allergens triggers a dual immune response: type 17 inflammation in the skin and T helper 2 sensitization in lymph nodes.
- γδ type 17-mediated dermatitis in early life leads to exaggerated allergic lung inflammation upon secondary allergen exposure.
- Dendritic cells (DCs) activate type 17 immune responses directly in the skin without migrating to lymph nodes, termed 'peripheral immune inducer' (pii) DCs.
- CD301b+ conventional type 2 DCs acquire allergens, adopt the pii-DC state, produce IL-23, and activate local γδ type 17 cells independently of lymph nodes.
- The pii-DC state is enabled by immature hypothalamic-pituitary-adrenal axis and low systemic glucocorticoids in early life.
- DC-specific deletion of the glucocorticoid receptor mimics the pii-DC phenotype.
- Neuroendocrine maturation sets a developmental checkpoint that shapes age-dependent allergic responses.