Regulation of STK38 by autophagy governs YAP1 activity during paligenosis - PubMed
7 hours ago
- #cellular plasticity
- #regeneration
- #autophagy
- Paligenosis is a cellular program allowing mature cells to reenter the cell cycle after injury.
- STK38 phosphorylates and deactivates YAP1 in uninjured cells, acting as a noncanonical kinase.
- During paligenosis stage 1, STK38 is degraded by autophagy, leading to YAP1 activation.
- YAP1 activation is essential for converting chief cells into metaplastic, proliferating progenitors.
- STK38 interacts with Merlin, linking it to the Hippo signaling pathway.
- The mechanism of YAP1 activation via autophagic STK38 degradation may apply across tissues.