Associations of Plasma Homocysteine Reflecting Vitamin B12 and Folate Status with Fatigue-Related Outcomes in Healthy Adults - PubMed

4 hours ago

Higher plasma homocysteine levels were linked to lower serum folate and vitamin B12 in both men and women.
In men, the highest homocysteine tertile was associated with higher physical fatigue scores compared to the lowest tertile.
In women, the highest homocysteine tertile was associated with lower motivation scores compared to the lowest tertile.
No significant associations were found when homocysteine was analyzed as a continuous variable.
The study's cross-sectional design suggests findings are exploratory and require further longitudinal research.

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