Cell cycle-dependent cues regulate temporal patterning of the Drosophila central brain neural stem cells - PubMed
4 days ago
- #Drosophila
- #neural stem cells
- #temporal patterning
- Drosophila type 2 neural stem cells (NSCs) generate diverse neurons and glia, regulated by temporal gene expression changes.
- The transition from early-to-late gene expression in NSCs involves the conserved gene seven-up and ecdysone receptor (EcR).
- Cell cycle progression and cytokinesis are essential for the early-to-late gene expression transition in NSCs.
- Arresting the NSC cell cycle or cytokinesis prevents downregulation of early genes and expression of late factors like EcR and Syncrip.
- Seven-up alone is insufficient to drive the early-late transition without proper cell cycle progression or cytokinesis.
- Both cell-intrinsic (cell cycle/cytokinesis) and extrinsic (hormonal) cues are required for NSC temporal patterning.