Multidimensional analysis of depression and diabetic kidney disease using GBD, NHANES, and MR - PubMed
7 hours ago
- #Depression
- #Mendelian Randomization
- #Diabetic Kidney Disease
- GBD 2023 data indicates rising burden of diabetic kidney disease (DKD) and high depression rates, especially in women and younger adults.
- NHANES 2013-March 2020 shows a strong cross-sectional association between depressive symptom severity and prevalent DKD, with severe symptoms conferring highest odds.
- Mendelian randomization (MR) analyses yielded predominantly null findings, with no robust evidence for a direct causal relationship.
- Nominal association between depressed affect and DKD observed in European ancestry populations attenuated after sensitivity analyses.
- Integration of mental health screening into diabetes care suggested to mitigate combined burden of depression and DKD.