Senescence-Driven IL-17A Inflammatory Circuit Promotes Epithelial-Mesenchymal Transition (EMT) and Progression in Age-Related Posterior Subcapsular Cataracts - PubMed
4 hours ago
- #epithelial-mesenchymal transition
- #posterior subcapsular cataracts
- #cellular senescence
- Senescence-driven IL-17A inflammatory circuit promotes EMT in age-related posterior subcapsular cataracts (PSC).
- PSC resembles posterior capsule opacification (PCO), suggesting LEC-EMT contributes to PSC.
- Transcriptomic profiling shows elevated EMT signatures in LECs of ARC-PSC linked to senescence-associated inflammation.
- Aqueous humor profiling reveals IL-17A is uniquely elevated in ARC-PSC.
- Senescent LECs release SASP factors, including IL-17A, activating NF-κB signaling to drive inflammation and EMT.
- Senolysis and IL-17A blockade disrupt the inflammatory loop, attenuating senescence- and EMT-associated phenotypes.
- Study positions ARC-PSC as a model to study senescence-induced epithelial remodeling in aging tissues.