Spatial and phenotypic plasticity of B cells in remodeling the tumor microenvironment - PubMed

7 hours ago

B cells exhibit dual roles in the tumor microenvironment, both promoting and restraining tumor progression.
In tertiary lymphoid structures, B cells mature and produce tumor-reactive antibodies that boost T-cell immunity.
In specific niches, B cells can adopt immunosuppressive phenotypes, suppressing T cells and aiding tumor progression.
Tumor-infiltrating antibodies, like IgA, have context-dependent effects based on antigen specificity and isotype.
Regulatory B-cell subsets are linked to resistance against immunotherapy and chemotherapy.
Strategies are needed to target pathogenic B cells while preserving their antitumor functions.

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