Alternating High-Fat and Polysaccharide Diets Modulates Gut Phage-Bacterial Interplay - PubMed
7 hours ago
- #dietary intervention
- #gut virome
- #phage-bacteria interaction
- Phages dominate the human gut virome and shape microbiota by preying on bacteria.
- Diet types, especially high-fat and polysaccharide-rich diets, strongly influence the gut virome and phage-bacterial interactions.
- High-fat diets increase phage abundance (34.21% to 50.00%) and drive phages toward a lytic lifestyle, enriching genes related to amino acid metabolism.
- Fucoidan reverses high-fat diet-induced dysbiosis and enhances phage-mediated horizontal gene transfer by 8.5-fold.
- CrAssphages and Parabacteroides phages play key roles in horizontal gene transfer and phage-host interactions during polysaccharide interventions.
- The study provides insights into diet-driven cross-kingdom interactions and potential nutritional interventions targeting gut microbiota.