Insight into the Hypoglycemic Effects of Pinus nigra Arn. Bark Extracts Through In Silico and In Vivo Analysis - PubMed

6 days ago

Diabetes mellitus is a major global health burden, with plant-derived polyphenols being explored for metabolic control.
Pinus nigra bark extract from Serbia was evaluated for its hypoglycemic potential using in silico and in vivo approaches.
Major constituents of P. nigra bark were docked against metabolic targets (LXRα, LXRβ, PTP1B, and SUR1) to assess potential effects.
In vivo tests on normoglycaemic and alloxan-induced diabetic Wistar rats showed the ethanol extract reduced glycaemia and improved glucose tolerance.
The extract also favorably modulated dyslipidaemia and showed additive effects when combined with metformin or gliclazide.
Further research is needed for comprehensive chemical profiling, mechanistic confirmation, and safety evaluation before translational consideration.

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