Thyroid hormones induce an acute platelet release mechanism via integrin αVβ3 - PubMed
a day ago
- #Platelet Production
- #Integrin αVβ3
- #Thyroid Hormones
- Thyroid hormones (T3 and its analogues) induce platelet production via integrin αVβ3.
- Peak platelet production occurs 4-8 hours post plateletpheresis.
- Proteomic and metabolomic analysis identified T3 and analogues (GC-1, MGL-3196, KB2115) as key mediators.
- Platelet production is enhanced in human cord blood and iPSC-derived MKs with thyroid hormone treatment.
- Integrin αVβ3 is the primary signaling pathway for thyroid hormone-induced platelet production.
- Silk-based 3D scaffold bioreactor technology significantly upscales platelet production.
- The findings have therapeutic potential in transfusion medicine.