Interconnection between Polycystic Ovary Syndrome, Immune Disorders, and Reproductive Outcomes - PubMed
3 hours ago
- #PCOS
- #Immune Dysregulation
- #Reproductive Outcomes
- PCOS is a multifactorial disorder linked to chronic low-grade inflammation and immune dysregulation.
- Women with PCOS show elevated inflammatory cytokines and immune cell infiltration in reproductive tissues, leading to oxidative stress, impaired steroidogenesis, and reduced endometrial receptivity.
- Adaptive immune imbalances, including Th1/Th2 and Th17/regulatory T cell shifts and autoantibodies, are associated with implantation failure and recurrent pregnancy loss.
- PCOS is frequently comorbid with autoimmune diseases like Hashimoto's thyroiditis and type 1 diabetes, indicating systemic immunometabolic imbalance.
- This review integrates systemic inflammation with localized immune dysregulation in reproductive tissues, offering a new framework for understanding PCOS pathophysiology.
- Metabolic therapies such as metformin and GLP-1 receptor agonists may improve immune balance, and targeted immunomodulation is a future prospect for specific PCOS subgroups.