AhR inhibition promotes axon regeneration via a stress-growth switch - PubMed
3 hours ago
- #AhR signaling
- #Axon regeneration
- #Stress-growth switch
- AhR inhibition promotes axon regeneration by shifting neuronal response from stress adaptation to growth.
- AhR activation in neurons after injury prioritizes proteostasis and stress-response programs.
- Deletion or pharmacological inhibition of AhR redirects neurons towards enhanced translation and pro-growth signaling.
- AhR ablation's regenerative effect requires HIF1α, with shared targets in metabolic and regenerative pathways.
- AhR regulon integrates environmental sensing, protein homeostasis, and metabolic signaling to control axonal repair.