Unveiling zhenwu decoction: A promising remedy for hypertensive heart failure via MAPKs/STAT2-NLRC5 pathway - PubMed
7 hours ago
- #inflammatory signaling
- #traditional Chinese medicine
- #hypertensive heart failure
- Zhenwu Decoction (ZWD) shows protective effects against angiotensin II (Ang II)-induced cardiac dysfunction in a hypertensive heart failure mouse model.
- The cardioprotective mechanism involves inhibition of cardiac hypertrophy and inflammation via the MAPKs/STAT2-NLRC5 signaling pathway, as revealed by RNA sequencing.
- Galloypaeoniflorin (GAL), an active component of ZWD, binds to STAT2 and alleviates inflammation in heart tissues and cardiomyocytes by targeting this pathway.
- Molecular docking, DARTS, CETSA, and SPR techniques confirm the binding between GAL and STAT2, supporting ZWD's potential in treating hypertensive heart failure.