Cuproptosis-related gene signatures define immune subtypes and predict prognosis in gastric cancer - PubMed
4 hours ago
- #immune subtypes
- #cuproptosis
- #gastric cancer
- Cuproptosis-related gene signatures define immune subtypes and predict prognosis in gastric cancer.
- Three distinct cuproptosis-associated molecular subtypes were identified in STAD.
- A five-gene prognostic signature (PEG10, RPL39L, MMP11, SYNPO2, KRT17) was established, showing strong associations with overall survival and immunological indicators.
- The prognostic signature is linked to immune cell infiltration, MSI, TMB, immune checkpoint expression, and HLA profiles.
- A nomogram was developed for enhanced individualized survival prediction.
- The study suggests previously unrecognized links between cuproptosis and antitumor immunity, potentially refining immunotherapeutic strategies in gastric cancer.
- Further experimental investigation is needed to validate the association between cuproptosis and immune regulation in gastric cancer.