Platelet NLRP6 protects against microvascular thrombosis in sepsis - PubMed
3 hours ago
- #Platelet NLRP6
- #Microvascular Thrombosis
- #Sepsis
- Platelet NLRP6 expression helps protect against microvascular thrombosis in sepsis.
- Platelet-specific NLRP6 knockout in mice increased mortality, microvascular thrombosis, and platelet activation.
- Deletion of NLRP6 enhanced platelet aggregation, granule release, and neutrophil extracellular trap (NET) formation.
- NLRP6 deletion promoted platelet NF-κB signaling by sustaining TAB1 expression, independent of inflammasome.
- NLRP6 facilitates TRIM21-mediated K48-linked ubiquitination and degradation of TAB1, suppressing NF-κB.
- Inhibition of NF-κB signaling reversed worsened thrombosis and NET formation in NLRP6-deficient sepsis models.
- Sepsis plasma triggers TAB1 degradation via NLRP6/TRIM21 in healthy platelets through TLR4/MyD88 pathway.